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Gynecology and fertility research focus on the female reproductive system, particularly the uterus, ovaries, and fallopian tubes, all crucial for reproduction. These organs are prone to dysfunctions like uterine fibroids, adenomyosis, and endometriosis, which impact fertility and health. These conditions can cause chronic pain, abnormal bleeding, and fertility issues, making research essential for better diagnostics and treatments. Additionally, malignant uterine lesions, such as sarcomas, require early detection to save lives. 

At the BM/d Lab, we focus on two main areas: predicting in-vitro fertilization (IVF) success and improving the diagnosis of uterine pathologies.  

In IVF research, we analyze uterine activity to assess receptivity before embryo transfer. Despite IVF's high cost, its success rate remains around 30%. We have developed advanced ultrasound strain imaging, both 2D and 3D, and analyzed uterine electrical activity (electrohysterogram) to predict IVF success. We also use clinical parameters and embryo quality data, employing machine learning algorithms to ultimately improve IVF outcomes by better understanding the relevant underlying factors. 

For uterine pathology, ultrasound analysis of uterine contractions helps diagnose conditions like adenomyosis, myomas, and post-caesarean niches by evaluating their impact on uterine peristalsis. Next to ultrasound strain imaging, we use texture analysis and quantitative contrast-enhanced ultrasound to assess angiogenesis, a key feature of conditions like adenomyosis and sarcomas, aiding in the differentiation of benign and malignant lesions. Advances in ultrasound localization microscopy and MRI further enhance diagnostic accuracy. 

To facilitate timely diagnosis by cost-effective monitoring through non-obtrusive technology, our research is also developing in the direction of perfusion monitoring by near infrared spectroscopy (NIRS), which can complement electrohysterographic monitoring of uterine activity in a multimodal fashion. 

Our research is conducted in collaboration with clinical partners including Catharina Hospital Eindhoven, University Hospital Ghent, Amsterdam University Medical Center, and Isala Hospital in Zwolle.