By optimizing the interaction between cells, engineered biomaterials, and biochemical and biophysical signaling cues, we develop novel tissue engineering strategies for regenerative purposes. Our ultimate goal is to achieve complete and long-lasting restoration of tissue functionality in the treatment of tissue defects or degenerative disorders. Many of our efforts are focused on regeneration in the joints, as damage and degeneration of joint tissues such as articular cartilage affect hundreds of millions worldwide, causing pain, disability, and a massive socioeconomic burden.
A central focus of our work is on mechano-driven and bottom-up approaches, in which we harness extrinsic and intrinsic mechanical forces to control cell behavior, guide tissue growth, and steer structural organization of the extracellular matrix. Our research integrates microtissue engineering, microfabrication, microscopy, molecular biology, biochemistry, and computational simulations, and is currently mainly focused on articular cartilage and intervertebral disc regeneration.