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Sebastien Callens is Assistant Professor in the Orthopaedic Biomechanics group of the Department of Biomedical Engineering and a core member of the Institute for Complex Molecular Systems. His research focuses on mechanoregeneration of orthopaedic soft tissues, with a current emphasis on articular cartilage. He is particularly interested in understanding how cartilage and other load-bearing tissues grow, self-organize, and develop highly structured extracellular matrices under the influence of mechanical and geometrical cues. By uncovering how tissue architecture emerges and how it governs function, degeneration, and repair, his work aims to establish new design principles for durable and functional regeneration. The group combines microtissue engineering, architectured biomaterials, quantitative microscopy, image analysis, and computational modelling to study and direct matrix organization across scales. Ultimately, this research seeks to translate fundamental insights in tissue mechanobiology into bottom-up and mechano-driven regenerative strategies for orthopaedic repair. His work has been recognized through several awards and fellowships, including the 2023 ON/EORS Orthoregeneration Award, an NWO Rubicon Fellowship, an EU Marie Sk艂odowska-Curie Fellowship, and the 2024 NWO Veni grant.

Sebastien Callens studied Aerospace Structures and Materials at Delft University of Technology, and obtained a PhD (cum laude) in Biomaterials and Tissue Biomechanics from the same university in 2021. His PhD centred around the design, development, and evaluation of complex porous scaffolds for bone tissue engineering, and was performed in the group of Prof. Amir Zadpoor. During his PhD, he was a visiting researcher in the Laboratory for Bone Biomechanics of Prof. Ralph M眉ller at ETH Zurich, supported by an IDEA League Exchange Grant. Afterwards, Sebastien joined the team of Prof. Molly Stevens at Imperial College London (and later at the University of Oxford), to work on cell-material interfaces for tissue engineering applications. For his postdoctoral research, he received a Rubicon Fellowship from NWO and a Marie Sk艂odowska-Curie Actions (MSCA) Fellowship from the EU. He also spent some months as a visiting researcher in the Biological Soft Matter group of Prof. Gijsje Koenderink at TU Delft. In September 2024, he joined the Department of Biomedical Engineering as Assistant Professor.