Departments of Applied Physics / Biomedical Engineering

Molecular Biosensing

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

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Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas

UPCOMING TECHNOLOGIES FOR CLINICAL IMMUNOLOGY

Work with us!

Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at 黑料福利网, please contact one of the staff members for more information.

 

Meet some of our Researchers

Recent Publications

Our most recent peer reviewed publications

About the research group

News

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March 25, 2026
Biosensors at the molecular scale: measuring what is almost impossible to measure
PhD candidate Chris Vu defended his thesis at the Department of Biomedical Engineering on March 24, 2026. As part of the Molecular Biosensing research group, he...
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January 19, 2026
Seeing the invisible: measuring crowded molecular coatings
Helen Tan defended her PhD thesis at the Department of Biomedical Engineering on January 19.
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More news
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Understanding and preventing signal drift in continuous biosensors
October 31, 2025
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Going for gold: How gold nanoparticles can revolutionise biosensing
April 10, 2025
f.L.t.R.:
NWO Vici grants awarded to Dani毛l Lakens and Peter Zijlstra
February 28, 2025
[Translate
Max Schelling Publishes Study on Cooling-Dependent Crystallization in Microgels in Soft Matter
August 29, 2024

Education

Check out our courses

The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

PhD Theses

Video on Plasmonic Biosensing using Metal Nanoparticles

Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].

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