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InPhoTerm: Integrated Photonics based Thermodilution curve measurement

Subject: Noninvasive assessment of cardiorespiratory status via ultrahigh resolution photonic thermometry

Thermodilution is the most widely-used method to measure cardiac output. It involves injecting a known volume of liquid upstream of the heart and then measuring temperature changes downstream. However, one of the disadvantages is its unreliability during routine examinations. Currently, there is no other widely used method to determine a patient's circulating blood volume status. Knowledge of this volume is essential for a complete understanding of complex cardiovascular and circulatory emergency situations like heart failure. 

InPhoTherm is a state-of-the-art project that utilizes integrated photonics to enable non-invasive thermodilution-based analysis. This cutting-edge technology offers early and accurate diagnosis at minimal cost and complexity. 

The new technology will first be developed and tested in clinical trials involving healthy volunteers, and later on patients during various medical procedures such as heart surgery, intensive care, cardiology, nephrology, emergency department, general ward, and even at home. 

Project:  InPhoTerm  | 2023-2028
Funded: Holland High Tech | TKI HSTM via the PPS allowance scheme for public-private partnerships, see 
Projectleader: Massimo Mischi | Supported by:  and Frans van der Vosse
Partners: Eindhoven University of Technology, Catharina Hospital, Amazec photonics

The project InPhoTerm is part of the Eindhoven MedTech Innovation Center (e/MTIC), a partnership between the Eindhoven University of Technology, Royal Philips, Catharina Hospital, Maxima Medical Centre and Kempenhaeghe Centre for Sleep and Epilepsy. This project is funded by Holland High Tech | TKI HSTM via the PPS allowance scheme for public-private partnerships.